Guardian of Genetic Messenger-RNA-Binding Proteins
نویسندگان
چکیده
منابع مشابه
Guardian of Genetic Messenger-RNA-Binding Proteins.
RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play important roles in the pathologies of a number of diseases. In this review we focus on the effec...
متن کاملRNA-binding proteins in human genetic disease.
RNA-binding proteins (RBPs) are key components in RNA metabolism, regulating the temporal, spatial and functional dynamics of RNAs. Altering the expression of RBPs has profound implications for cellular physiology, affecting RNA processes from pre-mRNA splicing to protein translation. Recent genetic and proteomic data and evidence from animal models reveal that RBPs are involved in many human d...
متن کاملMessenger RNA levels of guanine nucleotide-binding proteins are reduced in the ventricle of cardiomyopathic hamsters.
The expression of guanine nucleotide-binding protein (G-protein) genes (Gs alpha, Go alpha, Gi alpha 1, Gi alpha 2, and Gi alpha 3) was examined in the ventricle of cardiomyopathic Syrian hamsters of the Bio14.6 strain (10-35 weeks old). Northern blot analysis of total cellular RNA revealed that all G-protein genes except Gi alpha 1 were expressed in the ventricle of Syrian hamsters. Gs alpha a...
متن کاملThe proteins of the messenger RNA binding site of Escherichia coli ribosomes.
Oligo(U) derivatives with [14C]-4-(N-2-chloroethyl-N-methylamino)benzaldehyde attached to 3'-end cis-diol group via acetal bond, p(Up)n-1UCHRCl as well as with [14C]-4-(N-2-chloroethyl-N-methylamino)benzylamine attached to 5'-phosphate via amide bond, ClRCH2NHpU(pU)6 were used to modify 70S E. coli ribosomes near mRNA binding centre. Within ternary complex with ribosome and tRNAPhe all reagents...
متن کاملTranslation of the genetic message, iii. Formylmethionine as initiator of proteins programed by polycistronic messenger RNA.
Polyacrylamide gel electrophoresis of the virus-specific proteins synthesized in vivo upon infection of E. coli with phage AMS21 2 yields three main fractions designated as proteins I, II, and III, of which protein III is coat protein. Experimerits with "amber" mutants indicate that protein JI is a viral RNA synlthetase, whereas protein I12 ' is a "maturation" protein.4 Translation of the RNA o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomolecules
سال: 2016
ISSN: 2218-273X
DOI: 10.3390/biom6010004